Description

4-Phenyl-2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic compound class. This compound is of significant commercial interest for its role as a key building block in the research and development of novel therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Serves as a reference standard or probe in pharmacological assays to study specific biological pathways and receptor interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis methodology development and chemical biology studies.

Basic Information

Product Name	4-Phenyl-2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride
CAS No.	2044705-27-1
Molecular Formula	C15H19N2O·HCl
Molecular Weight	280.79 g/mol (Free base: 243.33 g/mol)
Synonyms	4-Phenyl-2,8-diazaspiro[4.5]decan-3-one hydrochloride; 2,8-Diazaspiro[4.5]decan-3-one, 4-phenyl-, hydrochloride; 4-Phenyl-2,8-diazaspiro[4.5]decan-3-one HCl; 4-Phenylspiro[2,8-diazabicyclo[3.3.1]nonane-3,1'-cyclopentane]-2-one hydrochloride; 2044705-27-1; Spirocyclic piperidine-pyrrolidinone hydrochloride derivative. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our 4-Phenyl-2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for advanced pharmaceutical intermediate applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.