Description

2-(Difluoromethyl)-5-Fluoropyridin-4-Amine Hydrochloride is a high-purity fluorinated pyridine derivative, a crucial building block in modern pharmaceutical and agrochemical research. Its value lies in its role as a versatile intermediate for synthesizing complex molecules, enabling the introduction of difluoromethyl and fluorine substituents to modulate biological activity and metabolic stability. This compound is essential for R&D chemists and process development scientists in the pharmaceutical industry, particularly for developing new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atoms enhance efficacy and environmental profile.
• Chemical Biology Probe Development: Serves as a precursor for creating labeled compounds or molecular probes to study biological pathways.
• Material Science Research: Potential intermediate for developing specialty chemicals, such as ligands for catalysts or monomers for advanced polymers.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production under cGMP conditions for clinical trial material.

Basic Information

Product Name	2-(Difluoromethyl)-5-Fluoropyridin-4-Amine Hydrochloride
CAS No.	2044705-13-5
Molecular Formula	C6H6ClF3N2
Molecular Weight	198.57 g/mol
Synonyms	4-Amino-2-(difluoromethyl)-5-fluoropyridine hydrochloride; 5-Fluoro-2-(difluoromethyl)pyridin-4-amine hydrochloride; 2-(Difluoromethyl)-5-fluoro-4-pyridinamine hydrochloride; 4-Pyridinamine, 2-(difluoromethyl)-5-fluoro-, hydrochloride (1:1); 2044705-13-5; 2-Difluoromethyl-5-fluoro-pyridin-4-ylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)-5-Fluoropyridin-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.