Description

2-(tert-Butyl) 8-Methyl 2,6-Diazaspiro[3.4]Octane-2,8-Dicarboxylate is a high-value, protected diazaspiro[3.4]octane derivative, a crucial building block in modern medicinal chemistry. Its rigid, three-dimensional spirocyclic scaffold is engineered to improve the drug-like properties of candidate molecules, including metabolic stability and target binding affinity. This compound is primarily sought after by pharmaceutical R&D and process chemistry teams for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its spirocyclic structure, which can confer favorable pharmacokinetic properties.
• Peptidomimetic Chemistry: Used to introduce conformational constraints into peptide backbones, enhancing stability and biological activity.
• Library Synthesis for Drug Discovery: Employed in high-throughput and parallel synthesis to create diverse compound libraries for screening against novel biological targets.
• Chemical Biology Probe Development: Utilized as a core structure for designing molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	2-(tert-Butyl) 8-Methyl 2,6-Diazaspiro[3.4]Octane-2,8-Dicarboxylate
CAS No.	2028341-88-8
Molecular Formula	C14H24N2O4
Molecular Weight	284.35 g/mol
Synonyms	tert-Butyl 8-methyl 2,6-diazaspiro[3.4]octane-2,8-dicarboxylate; 2,6-Diazaspiro[3.4]octane-2,8-dicarboxylic acid, 2-(1,1-dimethylethyl) 8-methyl ester; 2-(tert-Butoxycarbonyl)-8-(methoxycarbonyl)-2,6-diazaspiro[3.4]octane; 2-Boc-8-OMe-2,6-diazaspiro[3.4]octane; Diazaspiro[3.4]octane Boc-OMe protected building block
EINECS	Contact for details

Quality Control

Every batch of 2-(tert-Butyl) 8-Methyl 2,6-Diazaspiro[3.4]Octane-2,8-Dicarboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with advanced pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.