Description

m-Peg4-(Ch2)8-Phosphonic Acid Ethyl Ester is a specialized bifunctional PEG linker featuring a terminal phosphonic acid ethyl ester group. This compound is engineered to provide a versatile platform for bioconjugation and surface modification, offering a hydrophilic polyethylene glycol (PEG) spacer to enhance solubility and reduce immunogenicity. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotech, and materials science sectors who require precise molecular assembly for drug delivery systems, diagnostic probes, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: Used for linking bioactive molecules (e.g., peptides, antibodies, small molecule drugs) to surfaces, nanoparticles, or other polymers via the reactive phosphonic acid ester group.
• Surface Functionalization: Key for modifying metal oxide surfaces (e.g., titanium, iron oxide) in biomedical implants, biosensors, and contrast agents to improve biocompatibility and introduce specific functionalities.
• Drug Delivery Systems: Serves as a functionalized PEG spacer in the synthesis of targeted prodrugs and advanced constructs like antibody-drug conjugates (ADCs) and lipid nanoparticles (LNPs).
• Diagnostic Agent Synthesis: Employed in the development of imaging probes for MRI, PET, or fluorescence, where the PEG chain improves pharmacokinetics and the phosphonate group enables stable chelation or binding.
• Hydrogel and Biomaterial Crosslinking: Acts as a crosslinker or modifier to create tunable, hydrophilic networks for tissue engineering and controlled release applications.
• Organic Synthesis Intermediate: Provides a protected phosphonic acid derivative for further synthetic elaboration in medicinal chemistry and material science research.

Basic Information

Product Name	m-Peg4-(Ch2)8-Phosphonic Acid Ethyl Ester
CAS No.	2028281-89-0
Molecular Formula	C21H45O10P
Molecular Weight	488.55 g/mol
Synonyms	1-[8-(Diethoxyphosphoryl)octyl]triethylene glycol monomethyl ether; Phosphonic acid, P-[8-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]octyl]-, diethyl ester; mPEG4-C8-Phosphonate (diethyl ester); Diethyl (8-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)octyl)phosphonate; HO-PEG4-C8-P(O)(OEt)2; PEG-C8-Phosphonic acid diethyl ester; mPEG4-C8-Phosphonate Ester
EINECS	Contact for details

Quality Control

Our m-Peg4-(Ch2)8-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.