Description

Nangibotide CAS NO 2014384-91-7 is a synthetic peptide and a potent, selective inhibitor of TREM-1 (Triggering Receptor Expressed on Myeloid cells 1), a key modulator of the innate immune response. This compound is of significant interest for its potential to mitigate hyperinflammation associated with severe infections and autoimmune conditions. It is primarily utilized by pharmaceutical researchers and developers in the fields of immunology, sepsis, and inflammatory disease therapeutics.

Application

• Immunology Research: Used as a critical tool compound to study the TREM-1 signaling pathway and its role in inflammatory cascades.
• Preclinical Drug Development: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of novel anti-inflammatory therapeutics.
• Sepsis and Septic Shock Studies: Investigated for its potential to dampen the dysregulated immune response in preclinical models of severe systemic infection.
• Autoimmune Disease Research: Applied in research targeting conditions like rheumatoid arthritis, inflammatory bowel disease, and psoriasis where TREM-1 is implicated.
• Biochemical Assay Development: Employed as a standard in high-throughput screening (HTS) and in vitro assays to identify and characterize new TREM-1 inhibitors.
• Academic and Institutional Research: Supplied to universities and research institutes for fundamental studies in innate immunity and inflammation.

Basic Information

Product Name	Nangibotide
CAS No.	2014384-91-7
Molecular Formula	C42H68N14O13S
Molecular Weight	985.14 g/mol
Synonyms	LR12; LR-12 Peptide; TREM-1 Inhibitor Peptide; Ac-QSNDKIIHHLAQV-NH2; Nangibotide Acetate; UNII-2P5Q5QY9PJ; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamidopropanamido]-3-carboxypropanamido]-4-methylpentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-(1H-imidazol-5-yl)propanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-4-methylpentanamido]-3-(1H-indol-3-yl)propanamido]-5-(diaminomethylideneamino)pentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]acetamido
EINECS	Contact for details

Quality Control

Our Nangibotide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, content, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	5.0% - 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.