Description

Methyl 6-Fluoro-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylate Hydrochloride is a high-purity, fluorinated tetrahydroisoquinoline derivative, a crucial building block in modern pharmaceutical research and development. This compound matters for its role as a key synthetic intermediate in the creation of novel bioactive molecules, particularly in central nervous system (CNS) and oncology drug discovery pipelines. Pharmaceutical R&D chemists, contract research organizations (CROs), and fine chemical manufacturers need this material for its precise structural features that enable the exploration of new therapeutic agents. CAS NO 2007908-42-9 identifies this specific chemical entity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• API Development: Serves as a precursor in the development of Active Pharmaceutical Ingredients (APIs) containing the tetrahydroisoquinoline scaffold.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and receptor interactions.
• Library Synthesis: A valuable reagent for generating diverse compound libraries in high-throughput screening campaigns.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial production of complex molecules.

Basic Information

Product Name	Methyl 6-Fluoro-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylate Hydrochloride
CAS No.	2007908-42-9
Molecular Formula	C11H13FNO2·HCl
Molecular Weight	245.69 g/mol (Free base: 209.23 g/mol)
Synonyms	1-Carbomethoxy-6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; Methyl 6-fluoro-3,4-dihydro-1H-isoquinoline-1-carboxylate hydrochloride; 6-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid methyl ester hydrochloride; 6-Fluoro-THIQ-1-COOMe·HCl; MFTHIQ-C1-ester HCl; 2007908-42-9; 6-Fluoro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 6-Fluoro-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Assay (Titration)	98.0 - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.