Description

Azido-PEG6-CH2CO2T-butyl ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a protected carboxylic acid. This compound is essential for creating stable, water-soluble conjugates in bioconjugation and materials science, enabling click chemistry reactions with alkynes. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis for constructing drug delivery systems, diagnostic agents, and functional biomaterials.

Application

• Bioconjugation and ADC Development: A key reagent for site-specific conjugation of payloads to antibodies, proteins, or peptides via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry.
• PEGylation Reagent: Used to introduce PEG chains onto molecules to enhance solubility, reduce immunogenicity, and prolong circulation time in vivo for therapeutic agents.
• Polymer and Materials Science: Serves as a functional monomer or crosslinker for synthesizing smart hydrogels, surface coatings, and functionalized nanoparticles with tailored properties.
• Diagnostic Probe Synthesis: Facilitates the labeling of biomolecules (e.g., antibodies, oligonucleotides) with fluorescent dyes or other reporter molecules for imaging and diagnostic assays.
• Chemical Biology Tool: Enables the study of biomolecular interactions and cellular processes through the introduction of bioorthogonal handles onto target molecules.
• Linker for Solid-Phase Synthesis: Employed in peptide and oligonucleotide synthesis as a cleavable spacer or for the subsequent attachment of functional groups.

Basic Information

Product Name	Azido-PEG6-CH2CO2T-butyl ester
CAS No.	297162-49-3
Molecular Formula	C23H45N3O9
Molecular Weight	507.62 g/mol
Synonyms	1-Azido-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; Azido-PEG6-t-butyl ester; N3-PEG6-COOtBu; tert-Butyl 2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate; Azido-PEG6-acid t-butyl ester; PEG6 azide t-butyl ester; Azido-hexaethylene glycol-t-butyl ester; 2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Azido-PEG6-CH2CO2T-butyl ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and mass spectrometry for identity verification. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, moisture content (KF), and functional group integrity to ensure suitability for sensitive bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.