Description

Br-Peg6-Ch2Cootbu CAS NO 297162-48-2 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a bromo (Br) terminal group and a tert-butyl ester (Cootbu) moiety. This bifunctional linker is critical for introducing PEG spacers and specific reactive handles into target molecules, enhancing solubility and modifying pharmacokinetic properties. It is primarily utilized by researchers and process chemists in the pharmaceutical, bioconjugation, and advanced materials sectors for drug discovery, peptide synthesis, and polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Proteolysis-Targeting Chimeras (PROTACs): Used as a linker to connect E3 ligase ligands to target protein ligands, leveraging its length and solubility.
• Peptide Modification: Enables the site-specific PEGylation of peptides to improve stability and reduce immunogenicity.
• Polymer Chemistry: Acts as a functional initiator or monomer in the synthesis of tailored block copolymers and hydrogels.
• Crosslinking Agent: Utilized in material science for creating crosslinked networks with controlled spacer lengths.
• Surface Functionalization: Applied to modify nanoparticles and solid surfaces to introduce reactive bromo groups for further chemistry.

Basic Information

Product Name	Br-Peg6-Ch2Cootbu
CAS No.	297162-48-2
Molecular Formula	C25H49BrO10
Molecular Weight	589.56 g/mol
Synonyms	2,5,8,11,14,17-Hexaoxanonadecan-19-oic acid, 19-bromo-18-oxo-, 1,1-dimethylethyl ester; 1-Bromo-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; tert-Butyl 19-bromo-4,7,10,13,16,19-hexaoxa-3-azanonadecan-1-oate (common error, contains nitrogen); Bromo-PEG6-t-butyl ester; Br-PEG6-CH2COOtBu; Bromo-PEG6-acid tert-butyl ester; α-Bromo-ω-(tert-butoxycarbonyl) hexaethylene glycol
EINECS	Contact for details

Quality Control

Our Br-Peg6-Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is light-sensitive and should be handled under inert atmosphere when appropriate to maintain stability. Keep container tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.