Description

4-(n-tert-Butoxycarbonylamino)Tetrafluorophenylazide is a specialized heterobifunctional crosslinking agent and photoaffinity labeling reagent. This compound is critical for advanced bioconjugation and materials surface modification, enabling the covalent attachment of biomolecules under mild, light-activated conditions. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and the creation of functionalized polymers and diagnostic devices.

Application

• Photoaffinity Labeling (PAL): A key reagent for mapping protein-ligand interactions and identifying binding sites in drug discovery.
• Surface Functionalization: Used to create reactive azide monolayers on materials (e.g., gold, silicon) for subsequent "click chemistry" bioconjugation.
• Polymer Modification: Incorporation into polymer backbones or side chains to introduce photo-reactive crosslinking sites for hydrogel or smart material synthesis.
• Bioconjugation Linker: Serves as a heterobifunctional linker, connecting biomolecules (via the Boc-protected amine) to other entities via the light-activated aryl azide group.
• Proteomics Research: Employed in chemical proteomics for crosslinking and capturing transient protein complexes.
• Diagnostic Assay Development: Used to immobilize antibodies or antigens onto sensor surfaces in diagnostic chip manufacturing.

Basic Information

Product Name	4-(n-tert-Butoxycarbonylamino)Tetrafluorophenylazide
CAS No.	294187-76-1
Molecular Formula	C11H9F4N4O2
Molecular Weight	305.21 g/mol
Synonyms	4-(tert-Butoxycarbonylamino)-2,3,5,6-tetrafluorophenyl azide; 4-(Boc-amino)tetrafluorophenyl azide; 4-Azido-2,3,5,6-tetrafluoro-N-(tert-butoxycarbonyl)aniline; 2,3,5,6-Tetrafluoro-4-azidoaniline, N-Boc protected; Boc-NH-Tetrafluorophenylazide; Boc-4-Azido-2,3,5,6-tetrafluoroaniline; 4-(Boc-amino)perfluorophenyl azide; Heterobifunctional crosslinker, Boc-NH-PFPA
EINECS	Contact for details

Quality Control

Our 4-(n-tert-Butoxycarbonylamino)Tetrafluorophenylazide is manufactured under strict quality systems. Each batch is characterized and tested to ensure high purity and consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent degradation due to moisture and oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.