Description

1,2-Pyrrolidinedicarboxylic Acid, 5-(2-Propen-1-Yl)-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S)- is a high-purity, chiral pyrrolidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique stereochemistry and functional groups, enabling the construction of complex molecular architectures with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in protease inhibitor and neurological disorder research.
• Agrochemical Synthesis: Used in the development of advanced, enantiomerically pure pesticides and herbicides.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Peptidomimetic Research: Integral for creating proline-based peptidomimetics and constrained peptide analogs in medicinal chemistry.
• Fine Chemical Production: Employed in the custom synthesis of high-value specialty chemicals for electronics and material science.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis and stereochemistry at universities and corporate R&D labs.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 5-(2-Propen-1-Yl)-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S)-
CAS No.	291517-55-0
Molecular Formula	C16H25NO4
Molecular Weight	295.38 g/mol
Synonyms	(2S)-1-(tert-Butyl) 2-ethyl 5-(prop-2-en-1-yl)pyrrolidine-1,2-dicarboxylate; tert-Butyl (2S)-2-(ethoxycarbonyl)-5-(2-propen-1-yl)-1-pyrrolidinecarboxylate; (S)-1-Boc-2-(ethoxycarbonyl)-5-allylproline; 5-Allyl-1-Boc-2-(ethoxycarbonyl)-L-proline; 1-Boc-2-(ethoxycarbonyl)-5-allyl-(S)-proline; L-Proline, 5-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-; A chiral 5-allyl proline derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral GC, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and chiral purity specifications. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.