Description

(2R)-1-[[Chloro-(1-Oxidopyridin-5-Yl)Methylidene]Amino]Oxy-3-(1-Piperidyl)Propan-2-Ol is a high-purity chiral intermediate of significant interest in advanced pharmaceutical synthesis. Its complex molecular architecture, featuring a piperidine moiety and a pyridine N-oxide group, makes it a valuable building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of complex, high-value active pharmaceutical ingredients.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for ligands or catalysts in stereoselective reactions.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays and mechanism-of-action studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Item	Details
Product Name	(2R)-1-[[Chloro-(1-Oxidopyridin-5-Yl)Methylidene]Amino]Oxy-3-(1-Piperidyl)Propan-2-Ol
CAS No.	289893-25-0
Molecular Formula	C14H18ClN3O3
Molecular Weight	311.76 g/mol
Synonyms	(R)-1-(((Chloro(1-oxidopyridin-1-ium-5-yl)methylene)amino)oxy)-3-(piperidin-1-yl)propan-2-ol; 1-[[Chloro-(1-Oxidopyridin-5-Yl)Methylidene]Amino]Oxy-3-(1-Piperidyl)Propan-2-Ol, (2R)-; 289893-25-0; (2R)-1-(((Chloro(1-oxidopyridin-1-ium-5-yl)methylene)amino)oxy)-3-(piperidin-1-yl)propan-2-ol; Propan-2-ol, 1-[[chloro(1-oxido-5-pyridinyl)methylene]amino]oxy-3-(1-piperidinyl)-, (2R)-
EINECS	Contact for details

Quality Control

Our (2R)-1-[[Chloro-(1-Oxidopyridin-5-Yl)Methylidene]Amino]Oxy-3-(1-Piperidyl)Propan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support development projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.