Description

4-[2,2,2-Trifluoro-1-[(Trimethylsilyl)oxy]ethyl]morpholine is a specialized organosilicon building block featuring a trifluoroethyl and morpholine moiety, designed for advanced synthetic chemistry. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists seeking to introduce fluorinated and silyl-protected functional groups into target structures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoroethyl group can improve biological activity.
• Organofluorine Chemistry: Serves as a versatile reagent for introducing the -CH(OTMS)CF3 group into organic molecules, enabling the exploration of structure-activity relationships.
• Peptide Mimetics & PROTACs: The morpholine ring makes it suitable for constructing peptide backbones or linkers in Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules.
• Material Science Research: Potential precursor for developing specialty fluorinated polymers or surface-modifying agents with unique properties.

Basic Information

Product Name	4-[2,2,2-Trifluoro-1-[(Trimethylsilyl)oxy]ethyl]morpholine
CAS No.	289706-46-3
Molecular Formula	C11H20F3NO2Si
Molecular Weight	283.36 g/mol
Synonyms	4-(2,2,2-Trifluoro-1-[(trimethylsilyl)oxy]ethyl)morpholine; Morpholine, 4-[2,2,2-trifluoro-1-[(trimethylsilyl)oxy]ethyl]-; 2,2,2-Trifluoro-1-morpholin-4-yl-1-(trimethylsiloxy)ethane; 1-(Trimethylsiloxy)-1-(4-morpholinyl)-2,2,2-trifluoroethane; 4-(1-Trimethylsiloxy-2,2,2-trifluoroethyl)morpholine; TMS-protected Trifluoroethyl Morpholine
EINECS	Contact for details

Quality Control

Our 4-[2,2,2-Trifluoro-1-[(Trimethylsilyl)oxy]ethyl]morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.