Description

Methyl 3-(Trifluoromethylsulfonyloxy)-2-Naphthoate is a high-value, multi-functional chemical intermediate featuring a reactive naphthoate ester and a trifluoromethanesulfonate (triflate) leaving group. This compound is critical for enabling advanced synthetic transformations, particularly in the construction of complex molecules where its triflate group facilitates efficient carbon-carbon and carbon-heteroatom bond formation. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in creating complex naphthalene-based scaffolds for oncology and CNS therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the triflate group for introducing fluorinated moieties to enhance bioactivity.
• Material Science Research: Serves as a monomer or precursor for creating specialized polymers and organic electronic materials with tailored optical or conductive properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings due to the high reactivity of the triflate leaving group.
• Fluorination Chemistry: The trifluoromethylsulfonyloxy group is instrumental in nucleophilic fluorination reactions to introduce fluorine atoms into target molecules.
• Ligand and Catalyst Development: Used to synthesize sophisticated ligands for asymmetric catalysis and organometallic complexes.

Basic Information

Product Name	Methyl 3-(Trifluoromethylsulfonyloxy)-2-Naphthoate
CAS No.	288402-18-6
Molecular Formula	C₁₃H₉F₃O₅S
Molecular Weight	334.27 g/mol
Synonyms	Methyl 3-((trifluoromethyl)sulfonyloxy)-2-naphthoate; 2-Naphthalenecarboxylic acid, 3-[(trifluoromethyl)sulfonyl]oxy-, methyl ester; Methyl 3-trifluoromethanesulfonyloxy-2-naphthoate; 3-Triflyloxynaphthalene-2-carboxylic acid methyl ester; Methyl 3-(triflyloxy)-2-naphthoate; 288402-18-6; Methyl 3-OTf-2-naphthoate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(Trifluoromethylsulfonyloxy)-2-Naphthoate adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is fully characterized by NMR (¹H, ¹³C, ¹⁹F), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for advanced pharmaceutical intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.