Description

Methylcobalamin Hydrate CAS NO 288315-09-3 is a biologically active form of Vitamin B12, distinguished by its methyl group ligand bound to the central cobalt ion. This compound is critical for neurological health, cellular energy production, and the synthesis of DNA and red blood cells. It is an essential ingredient for manufacturers in the pharmaceutical, nutraceutical, and advanced research sectors seeking a high-purity, bioavailable cobalamin source.

Application

• Pharmaceutical Formulations: Primary active ingredient in prescription and injectable medications for treating Vitamin B12 deficiency, pernicious anemia, and certain neurological disorders.
• Dietary Supplements & Nutraceuticals: Key component in high-end capsules, tablets, and sublingual lozenges marketed for energy support, cognitive function, and nerve health.
• Clinical & Biomedical Research: Used as a critical reagent in studies related to methylation cycles, homocysteine metabolism, and neurobiology.
• Fortified Foods & Beverages: Incorporated into specialized nutritional products, medical foods, and health drinks requiring a stable, bioavailable form of B12.
• Cell Culture Media: Serves as a growth factor in specific mammalian cell culture applications within biopharmaceutical production.
• Veterinary Pharmaceuticals: Formulated into injectables and feed additives for livestock and companion animals.

Basic Information

Product Name	Methylcobalamin Hydrate
CAS No.	288315-09-3
Molecular Formula	C63H91CoN13O14P • xH2O
Molecular Weight	Approx. 1344.4 g/mol (anhydrous basis)
Synonyms	Mecobalamin; Methylcobalamin; Methyl B12; Co-methylcobalamin; Vitamin B12b; Methylcob(III)alamin; (SP-4-2)-[(Coα)-(α-5,6-Dimethylbenzimidazolyl)]-Coβ-methylcobamide; Cobamamide (methyl derivative); MeCbl
EINECS	Contact for details

Quality Control

Our Methylcobalamin Hydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade expectations. A comprehensive Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and microbiological parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below, or under refrigeration at 2-8°C for short-term use. The product is hygroscopic (moisture-sensitive) and strictly light-sensitive; containers must be kept sealed under an inert atmosphere (nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Dark red crystalline powder or crystals
Identification (HPLC/UV)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 12.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Analysis	Total Aerobic Microbial Count < 1000 cfu/g Total Combined Yeasts/Molds < 100 cfu/g Absence of specified pathogens

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.