Description

Spiro[1,3-Dioxolane-2,1'(2'H)-Naphthalene]-5'-Carboxylic Acid, 3',4',6',7',8',8'A-Hexahydro-8'A-Methyl-6'-Oxo-, Methyl Ester (9Ci) (4'Ar, 5'R, 8'Ar) CAS NO 287401-07-4 is a complex spirocyclic organic compound that serves as a sophisticated chemical intermediate and building block in advanced synthetic chemistry. Its intricate fused-ring structure, featuring both a dioxolane and a partially hydrogenated naphthalene system, makes it a valuable precursor for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought by pharmaceutical R&D teams and specialty chemical manufacturers engaged in creating complex molecules with specific stereochemistry for high-value applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) or anti-inflammatory targets.
• Advanced Organic Synthesis: Used in research to construct complex polycyclic frameworks and spirocyclic compounds for material science and catalysis studies.
• Agrochemical Development: Potential intermediate for creating new, high-efficacy active ingredients with complex molecular architectures.
• Academic & Industrial Research: Serves as a model compound or starting material for methodological development in stereoselective synthesis and total synthesis projects.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring precise stereochemical control and high purity.

Basic Information

Product Name	Spiro[1,3-Dioxolane-2,1'(2'H)-Naphthalene]-5'-Carboxylic Acid, 3',4',6',7',8',8'A-Hexahydro-8'A-Methyl-6'-Oxo-, Methyl Ester (9Ci) (4'Ar, 5'R, 8'Ar)
CAS No.	287401-07-4
Molecular Formula	C16H20O5
Molecular Weight	292.33 g/mol
Synonyms	(4aR,5R,8aR)-8a-Methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydro-2H-spiro[naphthalene-1,2'-[1,3]dioxolane]-5'-carboxylic acid methyl ester; Methyl (4aR,5R,8aR)-8a-methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydro-2H-spiro[naphthalene-1,2'-[1,3]dioxolane]-5'-carboxylate; Spiro[1,3-dioxolane-2,1'(2'H)-naphthalene]-5'-carboxylic acid, 3',4',6',7',8',8'a-hexahydro-8'a-methyl-6'-oxo-, methyl ester, (4'aR,5'R,8'aR)-; CAS 287401-07-4.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Standard quality control includes comprehensive analytical testing via HPLC, GC, NMR, and chiral analysis to verify identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development projects with custom synthesis and can tailor purity grades to meet specific R&D or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.