Description

Cyclobutanecarboxylic Acid, 3-Ethyl-3-Hydroxy-1-Methyl-, cis- (9Ci) is a high-purity, synthetically derived chiral building block featuring a functionalized cyclobutane core. This compound matters for its unique stereochemistry and multifunctional groups, which make it a valuable intermediate in the synthesis of complex, biologically active molecules. Pharmaceutical and agrochemical research organizations need it for developing new active ingredients, particularly where the constrained geometry of the cyclobutane ring is critical for target binding and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the cis-substituted cyclobutane structure imparts specific biological activity.
• Advanced Material Precursor: Serves as a building block for specialty polymers and liquid crystals that require rigid, aliphatic components.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Flavor & Fragrance Chemistry: Potential intermediate for synthesizing musky or woody odorants with complex stereochemical profiles.
• Academic & Contract Research: Essential for chemical biology studies and medicinal chemistry programs exploring cyclobutane-based scaffolds.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Ethyl-3-Hydroxy-1-Methyl-, cis- (9Ci)
CAS No.	286442-90-8
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	cis-3-Ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid; (1R,3S)-3-Ethyl-3-hydroxy-1-methylcyclobutanecarboxylic acid (enantiomer); 1-Methyl-3-ethyl-3-hydroxycyclobutanecarboxylic acid, cis-; Cyclobutanecarboxylic acid, 3-ethyl-3-hydroxy-1-methyl-, cis-; 286442-90-8; cis-1-Methyl-3-ethyl-3-hydroxycyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-Ethyl-3-Hydroxy-1-Methyl-, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.