Description

Benzeneacetic Acid, α-[[1-[[[2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]Amino]Carbonyl]Propyl]Amino]-, Methyl Ester, (Alphas)- (9Ci) is a sophisticated, high-purity synthetic intermediate characterized by its protected functional groups, including a tert-butyldimethylsilyl (TBDMS) ether. This compound matters for its role as a critical building block in advanced organic synthesis, enabling the precise construction of complex molecules. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs) and other fine chemicals where stereochemical control and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and mimetics for drug discovery programs.
• Asymmetric Synthesis: Serves as a chiral auxiliary or protected intermediate in stereoselective chemical transformations.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacturing of complex organic molecules.
• Chemical Biology Probes: Utilized in the creation of labeled or modified compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for fine chemical producers offering bespoke synthesis services.

Basic Information

Product Name	Benzeneacetic Acid, α-[[1-[[[2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]Amino]Carbonyl]Propyl]Amino]-, Methyl Ester, (Alphas)- (9Ci)
CAS No.	285996-33-0
Molecular Formula	C26H38N2O4Si
Molecular Weight	470.69 g/mol
Synonyms	(αS)-α-[[1-[[[2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]amino]carbonyl]propyl]amino]benzeneacetic acid methyl ester; Methyl (S)-2-((1-(2-((tert-butyldimethylsilyloxy)methyl)phenylamino)-1-oxopropan-2-yl)amino)-2-phenylacetate; TBDMS-protected phenylglycine derivative; Chiral N-protected amino acid ester; Silyl ether protected synthetic intermediate.
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, α-[[1-[[[2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]Amino]Carbonyl]Propyl]Amino]-, Methyl Ester, (Alphas)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to fluoride/strong alkali; ensure it is stored separately from such materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.