Description

tert-Butyl [(6-Chloropyridin-3-Yl)Methyl]Carbamate is a high-purity, protected amine intermediate of significant importance in modern synthetic organic chemistry. Its primary value lies in serving as a versatile and critical building block for the synthesis of more complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams working on active pharmaceutical ingredients (APIs), agrochemicals, and advanced material science. The structural motif of the protected aminomethylpyridine is a key scaffold for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyridine moiety is a common active component.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics Research: Employed in the design and synthesis of peptide analogs and protease inhibitors due to its protected amine functionality.
• Chemical Biology Probes: Utilized as a starting material for developing molecular probes and tags for studying biological systems.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic compounds for clients.

Basic Information

Product Name	tert-Butyl [(6-Chloropyridin-3-Yl)Methyl]Carbamate
CAS No.	285119-72-4
Molecular Formula	C11H15ClN2O2
Molecular Weight	242.70 g/mol
Synonyms	Carbamic acid, N-[(6-chloro-3-pyridinyl)methyl]-, 1,1-dimethylethyl ester; tert-Butyl (6-chloropyridin-3-yl)methylcarbamate; Boc-6-chloro-3-pyridylmethylamine; N-Boc-6-chloro-3-picolylamine; N-(tert-Butoxycarbonyl)-6-chloro-3-picolylamine; (6-Chloro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester; tert-Butyl N-[(6-chloropyridin-3-yl)methyl]carbamate; 1,1-Dimethylethyl N-[(6-chloro-3-pyridinyl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl [(6-Chloropyridin-3-Yl)Methyl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and other demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.