Description

1-Cyclopentene-1-Carboxylic Acid, 3-Hydroxy-4-Methoxy-2,3-Dimethyl-5-Oxo-, Methyl Ester, (3R,4S)-Rel- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its complex, functionalized cyclopentene core, which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting specific biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecules with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct molecules with defined three-dimensional configurations, crucial for drug activity.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological studies in organic synthesis and catalysis.

Basic Information

Item	Details
Product Name	1-Cyclopentene-1-Carboxylic Acid, 3-Hydroxy-4-Methoxy-2,3-Dimethyl-5-Oxo-, Methyl Ester, (3R,4S)-Rel- (9Ci)
CAS No.	282715-38-2
Molecular Formula	C11H16O5
Molecular Weight	228.24 g/mol
Synonyms	Methyl (3R,4S)-rel-3-hydroxy-4-methoxy-2,3-dimethyl-5-oxo-1-cyclopentene-1-carboxylate; (3R,4S)-rel-3-Hydroxy-4-methoxy-2,3-dimethyl-5-oxo-1-cyclopentene-1-carboxylic acid methyl ester; 1-Cyclopentene-1-carboxylic acid, 3-hydroxy-4-methoxy-2,3-dimethyl-5-oxo-, methyl ester, (3R,4S)-rel-; Methyl 3-hydroxy-4-methoxy-2,3-dimethyl-5-oxo-1-cyclopentene-1-carboxylate (relative configuration); CAS 282715-38-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed using advanced analytical techniques, including HPLC, GC, and NMR, to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are available upon request, providing full transparency on specifications. We adhere to a quality management system suitable for supplying materials for research and development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.