Description

Carbamic Acid, [(1S)-2-Methyl-1-(2-Oxoethyl)Propyl]-, 1,1-Dimethylethyl Ester is a chiral, protected amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a high-purity building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptides, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate specific, sterically hindered amino acid motifs into peptide chains.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides temporary protection for the amine functionality during complex synthetic sequences.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and labeled compounds for mechanistic studies.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic molecules at gram to kilogram scale.

Basic Information

Product Name	Carbamic Acid, [(1S)-2-Methyl-1-(2-Oxoethyl)Propyl]-, 1,1-Dimethylethyl Ester
CAS No.	280758-01-2
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-4-methylpentanal; Boc-L-leucinal; N-Boc-L-leucinal; tert-Butyl N-[(2S)-1-oxo-4-methylpentan-2-yl]carbamate; (S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanal; N-(tert-Butoxycarbonyl)-L-leucinal; BOC-Leu-H
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1S)-2-Methyl-1-(2-Oxoethyl)Propyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess, meeting the stringent requirements of pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, well-ventilated area. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.