Description

1-[(2R)-2-Pyrrolidinylmethyl]-1H-Imidazole Dihydrochloride is a high-purity, chiral organic salt of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block or intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in process development and scale-up for clinical and commercial production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially for central nervous system (CNS) targets.
• Ligand & Catalyst Research: Used in the development of novel asymmetric catalysts or metal-organic frameworks (MOFs) due to its imidazole and pyrrolidine functional groups.
• Biochemical Tool Compound: Serves as a precursor or reference standard in biochemical assays and pharmacological studies.
• Process Chemistry: Employed in route scouting and optimization for the commercial manufacturing of enantiomerically pure pharmaceuticals.
• Academic Research: Utilized in universities and research institutes for synthetic organic chemistry and medicinal chemistry projects.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value chemical entities.

Basic Information

Product Name	1-[(2R)-2-Pyrrolidinylmethyl]-1H-Imidazole Dihydrochloride
CAS No.	278790-56-0
Molecular Formula	C8H15N3 · 2HCl
Molecular Weight	238.15 g/mol
Synonyms	(R)-1-(Pyrrolidin-2-ylmethyl)-1H-imidazole dihydrochloride; (2R)-1-(1H-Imidazol-1-ylmethyl)-2-pyrrolidinediium dichloride; 1-[(2R)-2-Pyrrolidinylmethyl]imidazole Dihydrochloride; (R)-Pyrrolidinylmethylimidazole Dihydrochloride; 1-[(R)-2-Pyrrolidinylmethyl]-1H-imidazole Dihydrochloride; 1-(2-Pyrrolidinylmethyl)imidazole Dihydrochloride (R-enantiomer); 278790-56-0
EINECS	Contact for details

Quality Control

Our 1-[(2R)-2-Pyrrolidinylmethyl]-1H-Imidazole Dihydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, NMR, and residual solvent analysis. Our quality standards are designed to meet the rigorous demands of pharmaceutical development and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.