Description

1,1-Dimethoxy-2-Isocyanatoethane is a specialized isocyanate derivative featuring a protected acetal group, offering unique reactivity for advanced chemical synthesis. This compound is valued for its role as a versatile building block, enabling the controlled introduction of isocyanate functionality into complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for creating novel intermediates, linkers, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring masked or protected functional groups.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where its unique structure can impart specific biological activity or environmental stability.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for producing specialty polyurethanes, coatings, and adhesives with tailored properties such as controlled degradation or specific surface characteristics.
• Bioconjugation & Linker Chemistry: Employed in the development of cleavable linkers for antibody-drug conjugates (ADCs) and other bioconjugates, leveraging the reactivity of the isocyanate and the lability of the acetal group.
• Material Science Research: Utilized in creating advanced organic frameworks, dendrimers, and smart materials that require precise spatial arrangement of reactive sites.
• Chemical Proteomics: Acts as a probe or reagent for labeling and studying protein function and interactions due to its reactive isocyanate group.

Basic Information

Product Name	1,1-Dimethoxy-2-Isocyanatoethane
CAS No.	277300-82-0
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	2-Isocyanato-1,1-dimethoxyethane; Ethane, 1,1-dimethoxy-2-isocyanato-; Acetaldehyde Dimethyl Acetal, 2-Isocyanato-; 2-Isocyanatoacetaldehyde Dimethyl Acetal; Isocyanatoacetaldehyde Dimethyl Acetal; (Dimethoxymethyl)methyl isocyanate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 1,1-Dimethoxy-2-Isocyanatoethane is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and functional group verification, to ensure consistency and compliance with high-purity standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.