Description

Ccr3 Antagonist CAS NO 275812-32-3 is a potent and selective small molecule inhibitor of the CC chemokine receptor 3 (CCR3), a key target in inflammatory and allergic disease pathways. This high-purity compound is critical for pharmaceutical research and development, enabling the study of eosinophil-mediated conditions such as asthma, allergic rhinitis, and atopic dermatitis. It serves as an essential reference standard and active pharmaceutical ingredient (API) intermediate for drug discovery teams and fine chemical suppliers targeting the immunology and respiratory therapy markets.

Application

• Pharmaceutical R&D: Core intermediate in the synthesis of novel CCR3-targeting therapeutics for allergic and inflammatory diseases.
• Reference Standard: Used as a certified reference material (CRM) in analytical method development and quality control for drug manufacturing.
• Biochemical Research: A key tool compound for in vitro and in vivo studies to elucidate the role of CCR3 in eosinophil recruitment and activation.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies for candidate drug molecules.
• High-Throughput Screening (HTS): Serves as a control or competitor in assays designed to discover new CCR3 antagonists.
• Fine Chemical Synthesis: A building block for the custom synthesis of more complex molecules in contract research and manufacturing (CRAM).

Basic Information

Product Name	Ccr3 Antagonist
CAS No.	275812-32-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CCR3 Antagonist; CCR3 blocker; Chemokine Receptor CCR3 Inhibitor; (2R)-2-[[4-[[(3R)-3-(1H-Indol-3-ylmethyl)-4-oxo-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazin-2-yl]carbonyl]piperazin-1-yl]carbonylamino]-3-phenylpropanoic acid; 275812-32-3; UNII-9K2K303W5U
EINECS	Contact for details

Quality Control

Our Ccr3 Antagonist is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Single Maximum Impurity	≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.