Description

Carbamic Acid, [(1S)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester is a chiral, propargylic carbamate derivative that serves as a valuable synthetic intermediate. This compound is significant for its role in constructing complex molecular architectures, particularly in the synthesis of bioactive molecules and advanced materials. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of advanced crop protection agents and pesticides, leveraging its propargylic functionality.
• Peptide Mimetics & PROTACs: Employed in the construction of peptide backbones and as a linker component in Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Asymmetric Catalysis Substrate: Serves as a test substrate or a chiral auxiliary in the development and optimization of new asymmetric catalytic reactions.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers and resins with tailored properties.
• Chemical Biology Probes: Utilized to create labeled probes or activity-based protein profiling (ABPP) agents due to its reactive alkyne group for "click chemistry" applications.

Basic Information

Item	Details
Product Name	Carbamic Acid, [(1S)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester
CAS No.	275388-05-1
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	(S)-tert-Butyl (3-hydroxybut-1-yn-1-yl)carbamate; (S)-tert-Butyl (1-hydroxy-3-butyn-2-yl)carbamate; (1S)-1-(Hydroxymethyl)-2-propynyl carbamic acid tert-butyl ester; (S)-N-Boc-3-butyn-2-ol; tert-Butyl N-[(1S)-1-(hydroxymethyl)prop-2-yn-1-yl]carbamate; (S)-tert-Butyl (1-hydroxymethyl-2-propynyl)carbamate; Boc-L-Butynolglycinol tert-butyl ester
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1S)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.