Description

4-(Trimethylsilylethynyl)Benzyl Alcohol is a versatile organosilicon intermediate featuring a benzyl alcohol group and a trimethylsilyl-protected alkyne moiety. This unique structure makes it a valuable building block for synthesizing complex molecules in advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams, as well as material scientists, for applications requiring precise molecular assembly and functional group manipulation.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring alkyne or benzyl alcohol functionalization.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where its silicon and alkyne groups contribute to specific biological activity or stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and advanced organic electronic materials.
• Liquid Crystal & OLED Development: Employed in the synthesis of organic semiconductors and liquid crystal molecules for display technologies.
• Click Chemistry: The protected alkyne group is a potential participant in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer chemistry.
• Organic Synthesis Building Block: Used in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Heck) to introduce complex aromatic systems into target molecules.

Basic Information

Product Name	4-(Trimethylsilylethynyl)Benzyl Alcohol
CAS No.	275386-60-2
Molecular Formula	C12H16OSi
Molecular Weight	204.34 g/mol
Synonyms	4-[(Trimethylsilyl)ethynyl]benzyl alcohol; (4-(Hydroxymethyl)phenyl)ethynyltrimethylsilane; 4-(Trimethylsilylethynyl)benzenemethanol; p-(Trimethylsilylethynyl)benzyl alcohol; TMS-Ethynyl Benzyl Alcohol; 275386-60-2; Benzyl alcohol, 4-[(trimethylsilyl)ethynyl]-
EINECS	Contact for details

Quality Control

Our production of 4-(Trimethylsilylethynyl)Benzyl Alcohol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.