Description

(R)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester CAS NO 274692-07-8 is a high-value, chiral pyrrolidine derivative serving as a critical building block in modern organic synthesis. Its primary importance lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals that require a stereochemically defined pyrrolidine scaffold.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and enzyme inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency of stereoselective reactions.
• Peptidomimetics and Protease Inhibitors: The cyanomethyl-pyrrolidine core is a valuable motif in designing compounds that mimic peptide structures for therapeutic applications.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target validation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity chiral intermediates.

Basic Information

Product Name	(R)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	274692-07-8
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	1-Boc-(R)-3-cyanomethylpyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-(cyanomethyl)pyrrolidine; tert-Butyl (R)-3-(cyanomethyl)pyrrolidine-1-carboxylate; (R)-3-(Cyanomethyl)-1-(tert-butoxycarbonyl)pyrrolidine; (R)-N-Boc-3-cyanomethylpyrrolidine; (R)-1-Boc-3-(cyanomethyl)pyrrolidine; (3R)-3-(Cyanomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; Pyrrolidine-1-carboxylic acid, 3-(cyanomethyl)-, 1,1-dimethylethyl ester, (3R)-
EINECS	Contact for details

Quality Control

Our (R)-3-Cyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research and GMP (Good Manufacturing Practice) starting material applications. We employ advanced analytical techniques, including chiral HPLC, to guarantee enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.