Description

(R)-2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol is a chiral, silicon-protected alcohol derivative, a crucial building block in asymmetric synthesis. Its value lies in providing a protected hydroxyl group with defined stereochemistry, enabling the controlled construction of complex pharmaceutical intermediates. This high-purity chiral synthon is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control for developing active ingredients and specialty chemicals. CAS No. 265309-82-8.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Used as a chiral auxiliary or building block in stereoselective reactions to introduce the (R)-configured carbon center into target molecules.
• Agrochemical Development: Serves as a starting material for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for transition metal catalysts used in enantioselective hydrogenation and cross-coupling reactions.
• Natural Product Synthesis: A valuable synthon for the total synthesis of complex natural products with defined stereocenters.
• Material Science Research: Used in developing chiral polymers and liquid crystals for advanced optical and electronic applications.

Basic Information

Product Name	(R)-2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol
CAS No.	265309-82-8
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	(R)-1-(tert-Butyldimethylsilyloxy)-2-propanol; (R)-2-[(tert-Butyldimethylsilyl)oxy]-1-propanol; (R)-1-Hydroxy-2-[(tert-butyldimethylsilyl)oxy]propane; (R)-TBDMS-protected 1,2-propanediol; (R)-1,2-Propanediol, 1-(tert-butyldimethylsilyl) ether; (R)-1-TBDMS-oxy-2-propanol; (R)-2-Hydroxypropyl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our (R)-2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. We provide comprehensive analytical data, including chiral HPLC or GC analysis to confirm enantiomeric excess (ee). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.