Description

[1-(3-Trifluoromethylphenyl)-1-Tosyl]Methyl Isocyanide is a specialized organic building block featuring a unique trifluoromethylphenyl and tosyl-protected isocyanide functional group. This compound matters for its role as a versatile intermediate in advanced organic synthesis, particularly in the construction of complex heterocycles and pharmaceutical scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the biological activity imparted by the trifluoromethyl group.
• Material Science: Serves as a building block for creating specialized polymers and organic electronic materials with tailored properties.
• Multicomponent Reaction (MCR) Chemistry: An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot synthesis of diverse compound libraries.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for introducing the isocyanide functional group into target molecules.
• Chemical Biology: Used as a probe or labeling agent in bio-conjugation and activity-based protein profiling studies.

Basic Information

Product Name	[1-(3-Trifluoromethylphenyl)-1-Tosyl]Methyl Isocyanide
CAS No.	263389-45-3
Molecular Formula	C16H12F3NO2S
Molecular Weight	339.33 g/mol
Synonyms	1-[(4-Methylphenyl)sulfonyl]-1-[3-(trifluoromethyl)phenyl]methanimidoyl Cyanide; 1-Tosyl-1-(3-trifluoromethylphenyl)methyl Isocyanide; α-Tosyl-α-(3-trifluoromethylbenzyl) Isocyanide; [1-(3-Trifluoromethylphenyl)-1-(p-tolylsulfonyl)]methyl Isocyanide; 3-Trifluoromethylbenzenemethanimidoyl Cyanide, 1-[(4-methylphenyl)sulfonyl]-; (3-Trifluoromethylphenyl)(tosyl)methyl Isocyanide; Isocyanomethane, [1-(3-trifluoromethylphenyl)-1-(p-toluenesulfonyl)]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to a quality management system to support our commitment to supply reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.