Description

α-(p-Tolylsulfonyl)-A-(Thien-3-Yl)Methyl)Isocyanide is a specialized organic building block featuring a unique combination of an isocyanide functional group with tosyl and thienylmethyl protecting groups. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the synthesis of heterocyclic compounds and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and catalyst development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those containing thiophene or isocyanide-derived heterocycles.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its reactive isocyanide group.
• Material Science: Acts as a building block for the creation of functional polymers, ligands for catalysis, and organic electronic materials.
• Medicinal Chemistry: Employed in multi-component reactions (MCRs) like the Ugi reaction to rapidly generate diverse chemical libraries for biological screening.
• Chemical Synthesis: Utilized as a protected isocyanide equivalent in complex organic synthesis, offering stability and controlled reactivity.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new reaction pathways in synthetic organic chemistry.

Basic Information

Product Name	α-(p-Tolylsulfonyl)-A-(Thien-3-Yl)Methyl)Isocyanide
CAS No.	263389-44-2
Molecular Formula	C14H13NO2S2
Molecular Weight	291.39 g/mol
Synonyms	α-[(p-Tolylsulfonyl)(3-thienylmethyl)amino]methyl isocyanide; 1-Isocyano-1-[(toluene-4-sulfonyl)(thiophen-3-ylmethyl)amino]methane; TosMIC Thienylmethyl Derivative; (p-Toluenesulfonyl)(3-thienylmethyl)aminoacetonitrile N-oxide; N-[(Isocyanomethyl)(thiophen-3-ylmethyl)amino]-4-methylbenzenesulfonamide; 263389-44-2; α-(Tosyl)(3-thienylmethyl)aminoacetonitrile
EINECS	Contact for details

Quality Control

Our α-(p-Tolylsulfonyl)-A-(Thien-3-Yl)Methyl)Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.