Description

Carbamic Acid, [(1S,3S,4S)-4-(Hydroxymethyl)Spiro[2.2]Pentyl]-, 1,1- is a specialized chiral building block featuring a unique spirocyclic structure. This compound is valued for its role as a key intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists working on novel therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder research.
• Asymmetric Synthesis: Used in the construction of complex molecular architectures requiring high stereochemical purity due to its defined (1S,3S,4S) configuration.
• Medicinal Chemistry: Serves as a scaffold for creating focused libraries in drug discovery programs targeting specific protein families.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Bioconjugation & Probe Development: The hydroxymethyl group provides a handle for further functionalization, useful in creating chemical probes for biochemical assays.

Basic Information

Product Name	Carbamic Acid, [(1S,3S,4S)-4-(Hydroxymethyl)Spiro[2.2]Pentyl]-, 1,1-
CAS No.	263136-77-2
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(1S,3S,4S)-4-(Hydroxymethyl)spiro[2.2]pentan-1-amine carbamate; 1-Amino-4-(hydroxymethyl)spiro[2.2]pentane-1-carboxylic acid (carbamic acid form); (1S,3S,4S)-1-Carbamoyl-4-(hydroxymethyl)spiro[2.2]pentane; Spiro[2.2]pentane-1-carboxamide, 4-(hydroxymethyl)-, (1S,3S,4S)-; Chiral spirocyclic carbamate building block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high stereochemical purity, critical for pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.