Description

4-Methyl-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a high-value organosilicon reagent and versatile triflate ester, primarily used as a key building block in advanced organic synthesis. Its significance lies in its role as a protected phenolic derivative and a potent electrophile for cross-coupling reactions, enabling the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially those requiring silicon-containing or sterically hindered aromatic systems.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions such as Suzuki-Miyaura, Stille, and Negishi couplings to form biaryl and other carbon-carbon bonds.
• Polymer & Materials Science: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials where the trimethylsilyl and triflate groups impart specific properties.
• Agrochemical Synthesis: Employed as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and stability.
• Protecting Group Chemistry: The trimethylsilyl group acts as a robust protecting group for phenols, which can be selectively removed under mild conditions.
• Catalyst & Ligand Development: Useful for synthesizing novel organometallic catalysts and ligands used in asymmetric synthesis and homogeneous catalysis.

Basic Information

Product Name	4-Methyl-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	262373-15-9
Molecular Formula	C11H15F3O3SSi
Molecular Weight	312.39 g/mol
Synonyms	2-(Trimethylsilyl)-4-methylphenyl trifluoromethanesulfonate; 4-Methyl-2-(trimethylsilyl)phenyl triflate; 2-(Trimethylsilyl)-p-cresyl triflate; 4-Methyl-2-(trimethylsilyl)phenol triflate; TMS-Cresyl Triflate; o-Trimethylsilyl-p-tolyl Trifluoromethanesulfonate; [4-Methyl-2-(trimethylsilyl)phenyl] trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to moisture and strong acids; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.