Description

Spiro[2.2]Pentanecarboxylic Acid, 1-Amino- (9Ci) is a high-value, structurally constrained spirocyclic building block featuring both a carboxylic acid and a primary amine functional group. This unique bifunctional nature makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel scaffolds, peptidomimetics, and active ingredients. Its rigid spiro[2.2]pentane core is prized for introducing three-dimensionality and influencing the conformational properties of target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the spirocyclic structure can enhance biological activity and environmental profile.
• Peptidomimetics & Conformationally Restricted Peptides: The rigid scaffold serves as a non-natural amino acid analog to stabilize peptide secondary structures and improve metabolic stability.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research for creating novel chiral ligands and metal-organic frameworks (MOFs).
• Material Science Precursor: Potential monomer or cross-linking agent for specialty polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tools to study biological pathways and protein interactions.

Basic Information

Item	Detail
Product Name	Spiro[2.2]Pentanecarboxylic Acid, 1-Amino- (9Ci)
CAS No.	259097-31-9
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	1-Aminospiro[2.2]pentane-1-carboxylic acid; 1-Amino-1-carboxyspiro[2.2]pentane; 1-Aminospiro(2.2)pentane-1-carboxylic Acid; Spiro[2.2]pentane-1-carboxylic acid, 1-amino-; 1-Azaspiro[2.2]pentane-1-carboxylic acid (tautomeric form); 1-NH2-Spiro[2.2]pentane-1-COOH; 1-Amino-spiro(2,2)pentane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Spiro[2.2]Pentanecarboxylic Acid, 1-Amino- (9Ci) is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.