Description

1-Piperidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a reactive ethynyl group on a piperidine scaffold. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for creating novel drug candidates, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Protease Inhibitor Research: Used in the development of protease inhibitors, leveraging the piperidine core for binding affinity.
• Kinase Inhibitor Scaffold: Serves as a versatile scaffold for constructing potent and selective kinase inhibitors in oncology research.
• Peptidomimetics: Incorporated into peptidomimetic compounds to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in click chemistry applications due to the reactive ethynyl group for labeling and bioconjugation.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents with novel modes of action.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester
CAS No.	255864-58-5
Molecular Formula	C12H19NO2
Molecular Weight	209.29 g/mol
Synonyms	tert-Butyl 2-ethynylpiperidine-1-carboxylate; 2-Ethynyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-2-ethynylpiperidine; N-Boc-2-ethynylpiperidine; Boc-2-ethynylpiperidine; 2-Ethynylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 2-ethynyl-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-2-ethynylpiperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.