Description

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt is a high-purity synthetic intermediate of significant pharmaceutical importance. This compound is valued for its precise stereochemistry and role in advanced synthetic pathways. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or precursor in pharmacological and metabolic studies.
• Process Chemistry Development: Serves as a critical material for optimizing scalable synthetic routes in R&D laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt
CAS No.	254452-96-5
Molecular Formula	C29H27CaFNO5
Molecular Weight	528.61 g/mol
Synonyms	Rosuvastatin Calcium Intermediate; (3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt; Calcium (3R,5R,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate; ZD4522 Calcium Salt Intermediate; BMS-284756 Calcium Salt Derivative
EINECS	Contact for details

Quality Control

Our (3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets exacting standards for pharmaceutical R&D. A detailed Certificate of Analysis (COA) with full traceability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,5R,6E isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.