Description

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt is a high-purity synthetic intermediate and active pharmaceutical ingredient (API) of significant commercial and research interest. Its complex stereochemistry and specific structure make it a critical building block for advanced pharmaceutical development. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug molecules, particularly in cardiovascular and metabolic disease research.
• Active Pharmaceutical Ingredient (API) Development: Used in the R&D and production of proprietary pharmaceutical compounds where its specific stereochemistry is essential for biological activity.
• Biochemical Research: Employed as a reference standard or tool compound in pharmacological studies to investigate enzyme inhibition and receptor binding mechanisms.
• Process Chemistry & Scale-Up: Utilized in process development and optimization for the commercial manufacturing of target APIs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt
CAS No.	254452-92-1
Molecular Formula	C29H27CaFNO5
Molecular Weight	528.61 g/mol
Synonyms	Rosuvastatin Calcium EP Impurity H; (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt; Calcium (3S,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxyhept-6-enoate; Rosuvastatin Impurity H (Calcium Salt); Rosuvastatin Related Compound H; ZD4522 Impurity H
EINECS	Contact for details

Quality Control

Our (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.