Description

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt is a high-purity, synthetic chemical intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its specific stereochemistry and structural complexity, which are critical for biological activity in advanced therapeutic candidates. It is primarily sought by R&D laboratories and pharmaceutical manufacturers engaged in the synthesis of novel small-molecule drugs, particularly in areas requiring sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for metabolic and cardiovascular disease research.
• Biochemical Research: Used as a reference standard or a precursor in biochemical assays and pharmacological studies to investigate enzyme inhibition or receptor binding.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes during process optimization and validation in GMP environments.
• Academic Research: Employed in university and institutional laboratories for methodological studies in asymmetric synthesis and medicinal chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt
CAS No.	254452-88-5
Molecular Formula	C29H27CaFNO5
Molecular Weight	543.61 g/mol
Synonyms	Rosuvastatin Calcium EP Impurity I; (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt; Calcium (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate; Rosuvastatin Impurity I (Calcium Salt); Rosuvastatin Related Compound I; ZD4522 Impurity I; CRESTOR Impurity I
EINECS	Contact for details

Quality Control

Our production of (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid Calcium Salt adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with research-grade and pharmaceutical intermediate specifications. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.