Description

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex stereochemistry and functional groups, which make it a critical building block for novel therapeutic agents. It is primarily sought after by R&D laboratories and pharmaceutical manufacturers engaged in the synthesis of targeted small-molecule drugs, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of investigational new drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or probe compound in enzymatic and receptor-binding studies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex organic molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and methodology development.

Basic Information

Product Name	(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid
CAS No.	254452-86-3
Molecular Formula	C29H28FNO4
Molecular Weight	473.54 g/mol
Synonyms	7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid; Pitavastatin intermediate; NK-104 intermediate; (3S,5R)-Pitavastatin lactone open-chain form; Livalo® synthetic intermediate; (E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxyhept-6-enoic acid
EINECS	Contact for details

Quality Control

Our (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure identity, potency, and purity. Certificates of Analysis (COA) detailing comprehensive HPLC, NMR, and MS data are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.