Description

Pyridine, 2-Chloro-6-[(Trimethylsilyl)Oxy]- (9Ci) is a specialized organosilicon-protected pyridine derivative, serving as a valuable synthetic intermediate. Its core value lies in providing a protected hydroxyl group on the pyridine ring, enabling selective functionalization in complex multi-step organic syntheses. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing functionalized pyridine or bipyridine cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the chloropyridine moiety is a critical pharmacophore.
• Ligand Precursor: Serves as a precursor for the synthesis of sophisticated nitrogen-containing ligands used in catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its modifiable aromatic system.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Protecting Group Strategy: The trimethylsilyloxy group acts as a temporary protecting group for the hydroxyl function, allowing for orthogonal reactivity in complex synthetic sequences.

Basic Information

Product Name	Pyridine, 2-Chloro-6-[(Trimethylsilyl)Oxy]- (9Ci)
CAS No.	252980-63-5
Molecular Formula	C8H12ClNOSi
Molecular Weight	201.72 g/mol
Synonyms	2-Chloro-6-(trimethylsilyloxy)pyridine; 6-Chloro-2-pyridinol trimethylsilyl ether; 2-Chloro-6-(trimethylsiloxy)pyridine; 2-Chloro-6-(trimethylsilyloxy)pyridine; 2-Chloro-6-(trimethylsilanyloxy)pyridine; 2-Chloro-6-[(trimethylsilyl)oxy]pyridine; 2-Chloro-6-(OTMS)pyridine; 6-Chloro-2-(trimethylsilyloxy)pyridine
EINECS	Contact for details

Quality Control

Our Pyridine, 2-Chloro-6-[(Trimethylsilyl)Oxy]- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.