Description

Carbamic Acid, [(1S)-1-(Hydroxymethyl)-1-Methylpropyl]-, 1,1-Dimethylethyl Ester is a specialized chiral carbamate derivative of significant interest in advanced organic synthesis. This compound matters as a key chiral building block and protective group intermediate, enabling the stereoselective construction of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value fine chemicals.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Serves as a crucial precursor for the development of enantiomerically pure drugs, particularly in central nervous system (CNS) and antiviral research.
• Amino Acid and Peptide Chemistry: Used as a protecting group for amino acids during peptide coupling and solid-phase peptide synthesis (SPPS).
• Agrochemical Research & Development: Employed in the synthesis of novel, chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis Ligand Precursor: Provides a scaffold for developing novel chiral ligands and organocatalysts.
• Custom Synthesis and Process Chemistry: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development and scale-up projects.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-(Hydroxymethyl)-1-Methylpropyl]-, 1,1-Dimethylethyl Ester
CAS No.	252953-46-1
Molecular Formula	C10H21NO3
Molecular Weight	203.28 g/mol
Synonyms	tert-Butyl (2S)-2-hydroxy-2-methylbutylcarbamate; (2S)-2-Hydroxy-2-methylbutylcarbamic acid tert-butyl ester; N-[(1S)-1-(Hydroxymethyl)-1-methylpropyl]carbamic acid 1,1-dimethylethyl ester; (S)-tert-Butyl (1-hydroxy-1-methylpropyl)carbamate; BOC-L-Threoninol derivative; Chiral tert-butyl carbamate protecting group
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development under a quality management system. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity are available upon request. Specifications can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.