Description

trans-1-Boc-3,4-Pyrrolidinedicarboxylic Acid, 3-Ethyl Ester is a high-purity, protected pyrrolidine derivative, a crucial chiral building block in modern organic synthesis. Its value lies in providing a versatile, stereochemically defined scaffold for constructing complex molecules, enabling precise control over the final product's architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other bioactive molecules targeting the central nervous system and metabolic diseases.
• Agrochemical Research: Used in constructing novel pesticide and herbicide candidates, leveraging its constrained pyrrolidine ring to influence biological activity and selectivity.
• Peptidomimetics Development: Serves as a proline analog or a rigid scaffold for creating peptide mimics with enhanced metabolic stability and binding affinity.
• Asymmetric Catalysis Ligand Precursor: The protected carboxylic acid and ester groups allow for further functionalization to create novel chiral ligands and organocatalysts.
• Chemical Biology Probe Synthesis: Utilized in building blocks for activity-based probes or molecular tools to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	trans-1-Boc-3,4-Pyrrolidinedicarboxylic Acid, 3-Ethyl Ester
CAS No.	252919-44-1
Molecular Formula	C₁₄H₂₃NO₆
Molecular Weight	301.34 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3,4-pyrrolidinedicarboxylic Acid 3-Ethyl Ester (trans); trans-1-Boc-3,4-pyrrolidinedicarboxylic Acid 3-Ethyl Ester; (3R,4S)-1-(tert-Butoxycarbonyl)-3,4-pyrrolidinedicarboxylic Acid 3-Ethyl Ester; (3S,4R)-1-(tert-Butoxycarbonyl)-3,4-pyrrolidinedicarboxylic Acid 3-Ethyl Ester; trans-1-N-Boc-3,4-pyrrolidinedicarboxylic Acid 3-Ethyl Ester; BOC-DL-3,4-Dehydropipecolic Acid 3-Ethyl Ester (related); Pyrrolidine-3,4-dicarboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, 3-ethyl ester, (3R,4S)-rel-
EINECS	Contact for details

Quality Control

Our trans-1-Boc-3,4-Pyrrolidinedicarboxylic Acid, 3-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.