Description

8-(2-Fluoro-4-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated and nitrated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the fluoronitrophenyl group.
• Medicinal Chemistry Building Block: Provides a spirocyclic scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules for academic and industrial research.
• Fluorinated Compound Development: Acts as a specialized source of a fluorine-substituted aromatic ring, a crucial feature for modulating the metabolic stability and bioavailability of target compounds.

Basic Information

Product Name	8-(2-Fluoro-4-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane
CAS No.	252336-82-6
Molecular Formula	C15H17FN2O4
Molecular Weight	308.31 g/mol
Synonyms	8-(2-Fluoro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-(2-fluoro-4-nitrophenyl)-; 2-Fluoro-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)nitrobenzene; 8-(2-Fluoro-4-nitrophenyl)-8-aza-1,4-dioxaspiro[4.5]decane; 252336-82-6; FC-NDP; FNDP-Spiroketal.
EINECS	Contact for details

Quality Control

Our 8-(2-Fluoro-4-Nitrophenyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, assay, and impurity profiles. Our quality management system is designed to meet the stringent requirements of pharmaceutical and fine chemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.