Description

Azido-PEG2-CH2CO2tBu is a bifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a protected carboxylic acid terminus. This compound is essential for facilitating click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the efficient conjugation of biomolecules, polymers, and small molecules. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science, where precise and stable cross-linking is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a spacer to link cytotoxic drugs to antibodies or targeting proteins via click chemistry.
• Polymer and Materials Functionalization: Serves as a building block for creating functionalized hydrogels, surfaces, and smart materials with tailored properties.
• Proteomics and Biomolecule Labeling: Enables site-specific labeling of peptides, proteins, and oligonucleotides for imaging, diagnostics, and assay development.
• Drug Delivery System Design: Incorporated into nanoparticle and liposome formulations to attach targeting ligands or create cleavable linkages.
• Chemical Biology Probes: A key intermediate in synthesizing activity-based probes for studying enzyme function and metabolic pathways.
• Cross-linking Agent: Used to create stable covalent bonds between different molecules in diagnostic kit and biosensor manufacturing.

Basic Information

Product Name	Azido-PEG2-CH2CO2tBu
CAS No.	251564-45-1
Molecular Formula	C13H25N3O5
Molecular Weight	303.36 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-azidoethoxy)ethoxy]acetate; Azido-PEG2-t-butyl ester; Azido-PEG2-acid t-butyl ester; 2,5,8-Trioxa-11-azadodecan-12-oic acid, 11-azido-, 1,1-dimethylethyl ester; Azido-PEG2-CH2COOtBu; N3-PEG2-COOtBu; t-Butyl azido-PEG2-acetate
EINECS	Contact for details

Quality Control

Our Azido-PEG2-CH2CO2tBu is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.