Description

Bicyclo[2.2.1]Heptan-2-Ol, Methanesulfonate, (1S,2R,4R)- (9Ci) is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is valued for its rigid bicyclic framework and functional handles, which are critical for constructing complex molecules with precise three-dimensional architecture. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic and stoichiometric asymmetric reactions to induce chirality in target molecules.
• Ligand and Catalyst Development: Serves as a core structure for designing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Academic and Industrial R&D: A valuable reference standard and starting material for method development and exploration of new chemical space in research laboratories.

Basic Information

Product Name	Bicyclo[2.2.1]Heptan-2-Ol, Methanesulfonate, (1S,2R,4R)- (9Ci)
CAS No.	251446-59-0
Molecular Formula	C9H16O4S
Molecular Weight	220.29 g/mol
Synonyms	(1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl methanesulfonate; (-)-exo-2-Norbornyl methanesulfonate; (1S,2R,4R)-exo-2-Norbornanol methanesulfonate; (1S,2R,4R)-2-Norbornyl mesylate; exo-(-)-2-Norbornyl mesylate; (1S,2R,4R)-Bicyclo[2.2.1]hept-2-yl methanesulfonate; Chiral norbornyl mesylate
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC/MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.