Description

1-Benzyl 6-Ethyl (S)-2-((tert-Butoxycarbonyl)Amino)-4-Oxohexanedioate is a high-purity, chiral intermediate of significant importance in advanced organic synthesis. Its core value lies in its role as a protected amino acid derivative, providing a crucial building block for the construction of complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly for the synthesis of peptide-based therapeutics and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for peptide and peptidomimetic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamic acid or aspartic acid analog, enabling the introduction of specific side-chain functionalities.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of inhibitors targeting various proteolytic enzymes.
• Chemical Biology Research: Employed as a tool compound for studying enzyme mechanisms, protein-protein interactions, and signal transduction pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clinical trials.

Basic Information

Product Name	1-Benzyl 6-Ethyl (S)-2-((tert-Butoxycarbonyl)Amino)-4-Oxohexanedioate
CAS No.	250291-82-8
Molecular Formula	C20H27NO7
Molecular Weight	393.43 g/mol
Synonyms	(S)-1-Benzyl 6-ethyl 2-((tert-butoxycarbonyl)amino)-4-oxohexanedioate; (S)-2-((tert-Butoxycarbonyl)amino)-4-oxohexanedioic acid 1-benzyl 6-ethyl ester; Boc-Asp(O-Benzyl)-OEt; Boc-L-Aspartic Acid β-Benzyl Ester α-Ethyl Ester; Ethyl Boc-Asp(OBzl)-OH; N-Boc-L-Aspartic Acid 1-Benzyl 6-Ethyl Ester; N-(tert-Butoxycarbonyl)-L-aspartic acid α-benzyl β-ethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Benzyl 6-Ethyl (S)-2-((tert-Butoxycarbonyl)Amino)-4-Oxohexanedioate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.