Description

Ethyl 2-Chloro-3,3,3-trifluoro-2-isocyanatopropanoate is a specialized fluorinated isocyanate ester building block. This compound is valued for its unique trifluoromethyl and isocyanate functional groups, which enable the synthesis of novel molecules with enhanced properties. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and performance polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those requiring trifluoromethyl groups for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine moiety enhances activity and environmental persistence.
• Polymer Modification: Serves as a reactive monomer for introducing fluorinated isocyanate groups into polyurethanes and other polymers to improve chemical resistance, weatherability, and surface properties.
• Liquid Crystal & OLED Materials: A precursor for fluorinated components in electronic display and lighting materials, contributing to improved dielectric anisotropy and performance.
• Cross-linking Agent: Functions as a high-performance cross-linker in specialty coatings, adhesives, and sealants to enhance durability and chemical resistance.
• Chemical Research & Development: A versatile reagent for exploring new synthetic pathways and creating fluorinated analogs of existing compounds in medicinal and materials chemistry.

Basic Information

Product Name	Ethyl 2-Chloro-3,3,3-trifluoro-2-isocyanatopropanoate
CAS No.	250261-39-3
Molecular Formula	C6H5ClF3NO3
Molecular Weight	231.56 g/mol
Synonyms	2-Chloro-3,3,3-trifluoro-2-isocyanatopropanoic Acid Ethyl Ester; Ethyl 2-Chloro-3,3,3-trifluoro-2-isocyanatopropionate; 2-Isocyanato-2-chloro-3,3,3-trifluoropropionic Acid Ethyl Ester; Ethyl α-Chloro-β,β,β-trifluoro-α-isocyanatopropionate; TFIC Ethyl Ester; Chlorotrifluoroisocyanatopropanoate Ethyl Ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Chloro-3,3,3-trifluoro-2-isocyanatopropanoate adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis of the isocyanate group.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.