Description

3-Pyridinecarboxamide, 6-(2S,3S,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-2-Pyrrolidinylmethyl- is a high-purity, structurally complex heterocyclic compound that serves as a critical building block in advanced pharmaceutical research and development. Its value lies in its precise stereochemistry and functional groups, which make it an essential intermediate for synthesizing novel therapeutic agents, particularly in the fields of neurology and metabolic disease. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially for neurological and metabolic disorder treatments.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies and receptor binding assays due to its specific molecular architecture.
• Process Chemistry: Serves as a critical starting material or intermediate in multi-step synthetic routes for complex molecule manufacturing under GMP conditions.
• Academic Research: Employed in universities and research institutes for methodological development in asymmetric synthesis and medicinal chemistry projects.
• Preclinical Development: Integral component in the synthesis of candidate drug molecules for pharmacokinetic and toxicology studies.

Basic Information

Product Name	3-Pyridinecarboxamide, 6-(2S,3S,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-2-Pyrrolidinylmethyl-
CAS No.	249503-35-3
Molecular Formula	C12H17N3O4
Molecular Weight	267.28 g/mol
Synonyms	6-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methylpyridine-3-carboxamide; (2S,3S,4R,5R)-2-[(5-Carbamoylpyridin-2-yl)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol; A Precursor to DNJ Derivatives; Iminosugar-Pyridine Hybrid; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, which are paramount for your downstream synthesis. Certificates of Analysis (COA) detailing specifications such as chiral purity by HPLC, residual solvents, and heavy metals are supplied with each shipment. Our quality commitment aligns with the standards expected for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.