Description

Paquinimod CAS NO 248282-01-1 is a potent and selective small molecule immunomodulator belonging to the quinoline-3-carboxamide class. This compound is of significant interest for its targeted mechanism of action in regulating specific immune pathways. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in immunology and autoimmune disease research.

Application

• Pharmaceutical Research & Development: A key investigational agent for studying immune modulation and developing novel therapeutics for autoimmune and inflammatory conditions.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and mechanism of action related to S100A9 signaling.
• Biochemical Assay Development: Serves as a critical reference standard and tool compound in high-throughput screening (HTS) and target validation assays.
• Autoimmune Disease Research: Investigated for potential applications in conditions such as systemic sclerosis, lupus, and rheumatoid arthritis.
• Academic Research: Employed in university and institutional labs for fundamental research into innate immunity and myeloid cell function.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	Paquinimod
CAS No.	248282-01-1
Molecular Formula	C₁₉H₁₇N₃O₃
Molecular Weight	335.36 g/mol
Synonyms	ABR-215757; AZD-3342; Paquinimod hydrate; 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide; Quinoline-3-carboxamide, 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydro-
EINECS	Contact for details

Quality Control

Our Paquinimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all test results against predefined specifications. Our standards align with ICH guidelines for impurities and stability, supporting regulatory filings for preclinical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.