Description

4-((tert-Butyldimethylsilyl)Oxy)Butan-1-Amine is a versatile organosilicon-protected amino alcohol building block, primarily used as a key intermediate in sophisticated organic synthesis. Its value lies in the orthogonal protection strategy it offers, where the tert-butyldimethylsilyl (TBDMS) group shields the hydroxyl functionality, allowing selective manipulation of the primary amine. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity intermediates for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, particularly in creating amine- and alcohol-containing pharmacophores.
• Peptide Mimetics & Modifications: Used to introduce protected amino-alcohol side chains into peptide chains, enhancing stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Protecting Group Chemistry: Utilized in complex synthetic routes where temporary protection of a hydroxyl group is required.

Basic Information

Product Name	4-((tert-Butyldimethylsilyl)Oxy)Butan-1-Amine
CAS No.	245660-15-5
Molecular Formula	C10H25NOSi
Molecular Weight	203.40 g/mol
Synonyms	4-(tert-Butyldimethylsilyloxy)butylamine; 4-(TBDMS-Oxy)butylamine; 4-(TBDMSO)Butan-1-Amine; 4-(tert-Butyldimethylsiloxy)-1-butanamine; 4-Aminobutyl tert-butyldimethylsilyl ether; 1-Amino-4-((tert-butyldimethylsilyl)oxy)butane; N/A-2163; 4-(TBDMSO)butylamine
EINECS	Contact for details

Quality Control

Our 4-((tert-Butyldimethylsilyl)Oxy)Butan-1-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.