Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyrrolopyridine core and sulfonyl protecting group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly for kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Serves as a core scaffold for constructing potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of bespoke compounds and non-commercial drug candidates.
• Biochemical Tool Compound Development: Utilized to create probes for studying specific enzyme functions and cellular signaling processes.
• Academic Research: Applied in university and institutional labs for fundamental research in heterocyclic and organic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 1-(Phenylsulfonyl)-
CAS No.	245064-80-6
Molecular Formula	C14H10N2O4S
Molecular Weight	302.31 g/mol
Synonyms	1-(Phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(phenylsulfonyl)-; 1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid; 1-(Phenylsulfonyl)-7-azaindole-3-carboxylic acid; 7-Azaindole-3-carboxylic acid, 1-(phenylsulfonyl)-; 1-Phenylsulfonyl-7-azaindole-3-carboxylic acid; 245064-80-6; 1-(Benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.