Description

(2R,3R)-Rel-3-Hydroxy-2-(2-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester is a high-purity chiral piperidine derivative, a critical building block in advanced pharmaceutical synthesis. Its defined stereochemistry and functional groups make it an essential intermediate for developing enantiomerically pure active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular research. This compound is primarily utilized by R&D laboratories, process chemists, and manufacturers in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, especially those targeting neurological pathways.
• Asymmetric Synthesis: Used in the construction of enantiomerically pure compounds due to its defined (2R,3R) stereochemistry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) and generic APIs.
• Catalyst and Ligand Precursor: The piperidine core and functional groups can be modified to create novel chiral catalysts or ligands for organic transformations.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	(2R,3R)-Rel-3-Hydroxy-2-(2-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester
CAS No.	244056-94-8
Molecular Formula	C16H21NO3
Molecular Weight	275.35 g/mol
Synonyms	(2R,3R)-3-Hydroxy-2-(prop-2-en-1-yl)piperidine-1-carboxylic acid benzyl ester; Benzyl (2R,3R)-3-hydroxy-2-(2-propenyl)-1-piperidinecarboxylate; Rel-(2R,3R)-3-Hydroxy-2-allylpiperidine-1-carboxylic acid benzyl ester; (2R,3R)-2-Allyl-3-hydroxypiperidine-1-carboxylic acid benzyl ester; Bn-Protected (2R,3R)-3-Hydroxy-2-allylpiperidine; Chiral Piperidine Ester Intermediate; CAS 244056-94-8
EINECS	Contact for details

Quality Control

Our (2R,3R)-Rel-3-Hydroxy-2-(2-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (for (2R,3R) isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.